DoxyPEP is a little pill you can take to prevent exposure to STIs. If you're looking for information on PEP and/or PrEP, which prevent exposure to HIV, check out our other article.
What is DoxyPEP?

Doxycycline Post-Exposure Prophylaxis (DoxyPEP) is an emerging strategy to prevent certain bacterial sexually transmitted infections (STIs). It involves taking the antibiotic doxycycline after unprotected sex to reduce the risk of acquiring STIs like syphilis and chlamydia.
How Does DoxyPEP Work?
DoxyPEP entails taking a 200 mg dose of doxycycline as soon as possible, ideally within 24 hours—but no later than 72 hours—after unprotected sex. Doing so aims to prevent the establishment of bacterial infections following exposure.
Who Benefits From DoxyPEP?
Research has shown that DoxyPEP is most effective in reducing the risk of syphilis and chlamydia among gay and bisexual men and transgender women.
Considerations and Risks
While DoxyPEP shows promise, it’s essential to consider potential risks:
Antibiotic Resistance: Overuse of antibiotics can lead to resistance, making infections harder to treat.
Side Effects: Doxycycline can cause side effects like nausea, sensitivity to sunlight, and digestive issues.
Consult Your Healthcare Provider
Before starting DoxyPEP, discuss it with a healthcare professional to determine if it’s suitable for you. They can provide guidance based on your health history and potential risks.
Stayed Informed
As research evolves, guidelines may change. Stay updated on the latest recommendations from trusted health sources.
DoxyPEP represents a proactive approach to STI prevention, offering an additional layer of protection for those at higher risk. However, it is crucial to use this strategy responsibly and in consultation with healthcare providers.
Get Tested Today
HIV testing is fast and easy. The Affordable Care Act ensures HIV screening is covered by health insurance without a copay, and some sites offer free testing without insurance.
Check out the STI Clinic Search to find out where you can be tested in South Florida.
References
Centers for Disease Control and Prevention. (2024). Doxy PEP for Bacterial STI Prevention. Retrieved from https://www.cdc.gov/sti/hcp/doxy-pep/index.html
NAM aidsmap. (2024). DoxyPEP: Using antibiotics to prevent STIs. Retrieved from https://www.aidsmap.com/about-hiv/doxypep-using-antibiotics-prevent-stis